Toxoplasma Gondii Cathepsin L Is the Primary Target of the Invasion Inhibitory Compound Lhvs*

TOXOPLASMA GONDII CATHEPSIN L IS THE PRIMARY TARGET OF THE INVASION INHIBITORY COMPOUND LHVS* Eric T. Larson, Fabiola Parussini, My-Hang Huynh, Jonathan D. Giebel, Angela M. Kelley, Li Zhang,, Matthew Bogyo, Ethan A. Merritt, Vern B. Carruthers From Medical Structural Genomics of Pathogenic Protozoa Consortium (MSGPP), Department of Biochemistry, University of Washington, Seattle, WA 98195-7742, Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109-5620, Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 *Address correspondence to: Vern B. Carruthers, PhD, Department of Microbiology and Immunology, University of Michigan School of Medicine, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-5620. Fax: 734-764-3562. E-mail: [email protected]